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Tissue Digestion - Technical Information

> Composition of Mammals
> Digestion of Radioiodine Labeled Tissues
> Efficacy Testing Results
> Formaldehyde Destruction
> Prion Destruction
> The Effect on Plant and Animal Tissues
> Water Usage

Efficacy Testing Results

Efficacy Testing and Discussion
Refer to the "WR² Process Efficacy Testing Results" table in the Brochure. WR² Process efficacy is due to the high temperature and duration of the process, which exposes all materials within the Tissue Digestor to a temperature of 300 degrees Fahrenheit for a standard 3 hours exposure time. The exposure is amplified by the fact that it is a wet, continuously agitated, process eliminating any possibility of cold spots. The thermal transfer properties of this wet system are substantially better than in a steam sterilization system. There are no known pathogens that can survive exposure to this time and temperature profile. In addition, all proteins, including prions, are destroyed by Alkaline Hydrolysis in the WR² Process.

Agents listed under the DHHS Final Rule
Additional Requirements for Facilities Transferring or Receiving Select Agents

Bacterial	Rickettsiae	Fungi
Bacillus anthracis Burkholderia (Pseudomanas) mallei Clostridium botulinum Yersinia pestis Brucella abortus, B. melitensis, B. suis Burkholderia (Pseudomonas) pseudomallei Francisella tularensis	Coxiella burnetti Rickettsia rickettsii Rickettsia prowazekii	Coccidioides immitis

The above bacteria, rickettsiae, and fungi would be destroyed in the same manner as the indicator organisms shown in the report to New York State

Viruses

Toxins

Crimean-Congo Hemorrhagic Fever virus South American Hemorrhagic Fever virus (Junin, Machupo, Sabia, Flexal Guanarito) Eastern Equine Encephalitis virusTick-borne Encephalitis complex viruses Viruses causing Hantavirus Pulmonary Syndrome Variola major virus (Smallpox virus) Venezuelan Equine Encephalitis virus Ebola virus Lassa Fever virus Equine Morbillivirus Marburg virus Yellow Fever virus Rift Valley Fever virus

Abrin Aflatoxins Botulinum toxins Clostridium perfringens Epsilon toxin Conotoxins Diacetoxyscirpenol Ricin Saxitoxin Shigatoxin Staphylococcal enterotoxin Tetrodotoxin T-2 toxin

Protein toxins would be hydrolyzed in the same manner as any other protein
Nonprotein toxins would be destroyed as shown in subsequent pages

Recombinant Organisms/Molecules
Recombinant organisms and molecules shown to produce or encode for a factor associated with a disease would be destroyed in the same manner as natural organisms

Recombinant organisms or nucleic acid sequences coding for any of the toxins listed above or their toxic subunits would be destroyed in the same manner as normal nucleic acids and nucleotides